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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
https://www.microscope.healthcare.nikon.com/products/upright-microscopes/eclipse-e200
Educational microscope. Designed as simple system that reduces fatigue from use over long periods. With structure and anti mold design, offers high quality and accuracy that can be retained for years even in hot and humid environments.
Proper citation: Nikon: Eclipse E200 microscope (RRID:SCR_021243) Copy
https://www.microscope.healthcare.nikon.com/en_EU/products/inverted-microscopes/eclipse-ti-series
ECLIPSE Ti Series of inverted microscopes combined with Nikon NIS-Elements imaging acquisition and analysis software, enables to generate data faster, more easily, and more accurately than ever before.Product Discontinued. Replaced by ECLIPSE Ti2 Series.
Proper citation: Nikon: ECLIPSE Ti inverted microscope system (RRID:SCR_021242) Copy
System for long term volumetric imaging of living cells. Makes light sheet fluorescence microscopy available for live cell imaging at subcellular resolution. Automated system for volumetric imaging of subcellular structures and dynamics over hours and days with protection from photo damage.
Proper citation: Zeiss: Lattice Lightsheet 7 (RRID:SCR_021237) Copy
https://diagnostics.roche.com/us/en/products/instruments/discovery-ultra-research.html
Immunohistochemistry processor that can be used for immunohistochemistry and in situ hybridization slide preparation and processing. With 30 individual slide drawers, DISCOVERY ULTRA system enables to run both manual and fully automated experiments simultaneously with nosynchronization errors. Provides ability to fully automate broad range of IHC and ISH assays, including FISH, gene and protein IHC/ISH, mRNA ISH and multiplex assays with any combination of IHC and ISH.
Proper citation: Roche: Ventana DISCOVERY Ultra (RRID:SCR_021254) Copy
https://github.com/PIEFoundry/Microfabrication/wiki/Parylene-MEA-Fabrication
Parylene MEA Fabrication is related to SPARC. Repository for standard fabrication procedure for Parylene C microelectrode arrays and similar devices.
Proper citation: HORNET CENTER FOR AUTONOMIC NERVE RECORDING AND STIMULATION SYSTEMS (RRID:SCR_023681) Copy
http://jsu.eagle-i.net/i/0000012b-00bd-5152-3984-bcfb80000000
A research laboratory and facility which supports research on environmental toxicology at Jackson State University.
Proper citation: JSU Environmental Toxicology Core Lab (RRID:SCR_000884) Copy
http://edboyden.org/05.09.boyden.html
Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells.
Proper citation: Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Copy
Core laboratory for nucleic acid sequencing and bioinformatics. Used for research support, education, and training. Services include genomic techniques and applications, sequencing technologies, and bioinformatics analyses, writting letters of support for grant applications submitted to funding agencies. GGBC operates multiple platforms for short-, long-, and single-molecule sequencing reads (i.e., Illumina MiSeq and NextSeq, PacBio Sequel, and Oxford Nanopore MinIon).
Proper citation: Georgia Genomics and Bioinformatics Core at the University of Georgia (RRID:SCR_010994) Copy
http://www.med.upenn.edu/molecular/core_morphology.shtml
Core facility that provides histological services, equipment usage, and technical expertise to digestive and liver research projects.
Proper citation: University of Pennsylvania Center for Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core (RRID:SCR_015618) Copy
https://www.spscientific.com/AboutOurTrustedBrands/
Commercial organization located in Warminster, Pennsylvania, USA, part of SP Industries, Inc. Provides VirTis, FTS Systems, Hotpack, Hull, Genevac, and PennTech scientific equipment. Manufactures freeze drying/lyophilization, centrifugal evaporation and concentration, temperature control/thermal management, glassware washers, controlled environments, vial washing and tray loading machines., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: SP Scientific (RRID:SCR_017367) Copy
https://www.bruker.com/about-us.html
Commercial organization located in Massachusetts, USA, for scientific instruments and analytical and diagnostic solutions. Bruker equipment can be used in life science molecular research, in applied and pharma applications,microscopy, nano-analysis and industrial applications. Provider of high-performance systems for cell biology, preclinical imaging, clinical phenomics and proteomics research, clinical microbiology, and for molecular pathology research.
Proper citation: Bruker Corporation (RRID:SCR_017365) Copy
http://www.rockefeller.edu/bioimaging/
Provide members of University and their visitors with wide spectrum of optical microscopy equipment and extensive training in its use.
Proper citation: Rockefeller University Bio-Imaging Resource Center Core Facility (RRID:SCR_017791) Copy
Core provides access to biophysics equipment, integral to research community at University of Chicago.Provides tools, training, and assistance for quantitative analysis of macromolecules and their interactions. Instruments include Seahorse XFe-96 Extracellular Flux Analyzer,Jasco J-1500 CD Spectrometer,Synergy Neo HST Plate Reader,Wyatt DAWN HELEOS II SLS,Wyatt DynaPro Plate Reader DLS,Wyatt DynaPro NanoStar DLS,HORIBA Fluorolog-3,Microcal iTC200,Molecular Imager,Bio-Rad ProteOn XPR to Biacore 8K,Agilent 8453 Spectrophotometer. Core provides staff assistance in conducting experiments.
Proper citation: Chicago University Biophysics Core Facility (RRID:SCR_017915) Copy
https://www.brown.edu/research/projects/superfund/cores/core-d
Core provides equipment and technical expertise for evaluation of molecular and morphological changes in cells, tissues, and organs following exposure to complex environmental contaminants. Provides equipment, including automated tissue processor, paraffin embedding center, two automated microtomes, cryostat, vibratome for soft-tissue sectioning, multiheaded light microscope with projection capabilities, system for laser capture microdissection, and slide scanner with analysis software for identification and quantification of morphological structures.Offers expertise in histopathological and immunocytochemial methods, including fixation, dehydration, embedding, sectioning, histological staining, immunolabeling, high-resolution imaging, and quantitative image analysis. Services in sample preparation, offers assistance in imaging and image analysis and provides consultation for ongoing or future research projects, training program for students and investigators who use centrally available equipment.
Proper citation: Brown University Molecular Pathology Core Facility (RRID:SCR_017898) Copy
https://www.igb.illinois.edu/corefacilities
Core for biological microscopy and image analysis. Offers high-end equipment,user training,ongoing support, including experiment design and data interpretation,twenty-four hour access Services,3D Printing, Transfer Files, Image Analysis,Histology,Instrument Training.
Proper citation: University of Illinois at Urbana-Champaign Core Facilities at IGB (RRID:SCR_017938) Copy
Core provides access to fluorescence microscopy equipment including Deltavision OMX Blaze Super Resolution (3D-SIM/SMLM), Leica SP8 inverted confocal, La Vision Ultramicroscope II Lightsheet Microscope,Nikon Andor WD spinning disk, Nikon A1R inverted confocal x2, Olympus FV-MPERS Multi Photon,Olympus FV3000 inverted confocal (live cell) ISS Fast-FLIM, Perkin Elmer Operetta High Content Imaging, Zeiss LSM800 upright Airyscan, Zeiss LSM880 upright Airyscan fast, Zeiss Elyra/LSM880 inverted (live cell), super resolution (Airyscan/SMLM). Staff can help with image analysis, super resolution microscopy, fluorescence lifetime imaging microscopy, high content imaging and light sheet microscopy techniques.
Proper citation: University of Melbourne Biological Optical Microscopy Platform (BOMP) Core Facility (RRID:SCR_018888) Copy
Analyzer applies BD FACSymphony instrument technology to reduce background noise and increase detection sensitivity. Features low-noise electronics, high-powered lasers and tight beam spot to support immunophenotyping up to 16 colors. Enables independent analysis of large and small particles on single instrument. Optional small particle detector enables detection of small particles such as extracellular vesicles, viral particle and more. Compatible with broad portfolio of catalog and custom BD Horizon Brilliant Reagents and BD FACSDiva Software. Permits easy placement on standard lab bench with its compact format.
Proper citation: BD Biosciences: FACSymphony A1 Cell Analyzer (RRID:SCR_024830) Copy
https://www.3dhistech.com/research/pannoramic-digital-slide-scanners/pannoramic-midi/
Automatic digital slide scanner with 12 slide capacity in one run, fluorescence scanning, 9 physical filter cubes and 45 logical fluorescence channels. Powered by PANNORAMIC Scanner Software. Supports Carl Zeiss objectives, achieving up to 43x or 86x magnification and 0.087 µm/pixel resolution within the same instrument, along with advanced FISH scanning technique.
Proper citation: 3DHISTECH: PANNORAMIC MIDI II scanner (RRID:SCR_024834) Copy
https://site.research.utexas.edu/cbrs/
Facility provides access to and operational support for easy-to-operate equipment for sample preparation and analysis, including gel imagers, plate readers, and qPCRs. They provide training on instrument operation and grant access for independent use after completed training.
Proper citation: University of Texas at Austin Shared Instrumentation Facility (RRID:SCR_026271) Copy
https://icahn.mssm.edu/research/human-immune-monitoring-center
Core provides team of experts in the characterization of immune profiles and treatment responses across a diverse range of diseases, such as cancer, autoimmunity, allergy, and neuro-immune disorders. Offers equipment in the field for research at Genomic, cellular and proteomic analysis. Develops assays to balance innovation with protocols and operating procedures to ensure data quality and reproducibility.
Proper citation: Icahn School of Medicine at Mount Sinai Human Immune Monitoring Center Core Facility (RRID:SCR_027571) Copy
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