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URL: http://www.wormbase.org/db/get?name=WBStrain00008559
Proper Citation: RRID:WB-STRAIN:WBStrain00008559
Description: Caenorhabditis elegans with name lin-41(xe8)/+ I. from WB.
Species: Caenorhabditis elegans
Synonyms: lin-41(xe8)/+ I.
Notes: Heterozygous stock. Maintain strain by picking Egl heterozygous animals. xe8/xe8 homozygotes burst at the vulva. Heterozygous animals have egglaying defects (Egl). xe8 is a partial deletion of the lin-41 3'UTR eliminating ~450 nt that includes the two let-7 complementary sites (LCS) [I:9,335,206 - 9,335,654]. xe8 is a gain-of-function allele: elimination of two functionally relevant let-7 binding sites relieves repression by let-7 causing overexpression of LIN-41 in L4 stage animals. Reference: Ecsedi M, et al. Dev Cell. 2015 Feb 9;32(3):335-44. Do not distribute this strain; other labs should request it directly from the CGC. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects.|"Made_by: Matyas Escedi"|"No longer available from the CGC"
Affected Gene: WBGene00003026(lin-41)
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Source: WormBase (RRID:SCR_003098)
Description: Central data repository for nematode biology including complete genomic sequence, gene predictions and orthology assignments from range of related nematodes.Data concerning genetics, genomics and biology of C. elegans and related nematodes. Derived from initial ACeDB database of C. elegans genetic and sequence information, WormBase includes genomic, anatomical and functional information of C. elegans, other Caenorhabditis species and other nematodes. Maintains public FTP site where researchers can find many commonly requested files and datasets, WormBase software and prepackaged databases.
URL: http://www.wormbase.org
Source Database: WormBase (WB)