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URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=728195
Proper Citation: RRID:RRRC_00231
Description: Rattus norvegicus with name SHR/N-cp from RGD.
Species: Rattus norvegicus
Notes: The spontaneously hypertensive corpulent (SHR/N-cp) rat developed at the National Institutes of Health (NIH) is a congenic strain in which obese homozygotes {cp/cp) are characterized by genetic obesity, mild hypertension, hyper-insulinemia, and glucose intolerance. This rat strain was initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female SHR ratof the Okamoto strain. A minimum of 12 backcrosses were carried out to eliminate the non-cp genes of the Ko-letsky strain. The obese (cp/cp) littermates develop glucosuria, proteinuria, and renal structural lesions resemblingdiabetic glomerulosclerosis. Rat Resource and Research Center
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Source: Rat Resource and Research Center (RRID:SCR_002044)
Description: Supplies biomedical investigators with rat models, embryonic stem cells, related reagents, and protocols they require for their research. In addition to repository, cryostorage and distribution functions, RRRC can facilitate acquisition of rat strains from other international repositories as well as provide consultation and technical training to investigators using rat models.
URL: http://www.rrrc.us/
Source Database: Rat Resource and Research Center (RRRC)
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