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Organism Name

B6.Cg-B2m^tm1Jae Tap1^tm1Hpl/Mmucd

RRID:MMRRC_032245-UCD RRID Copied

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RRID:MMRRC_032245-UCD

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Organism Information

URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32245

Proper Citation: RRID:MMRRC_032245-UCD

Description: Mus musculus with name B6.Cg-B2m^tm1Jae Tap1^tm1Hpl/Mmucd from MMRRC.

Species: Mus musculus

Notes: Research areas: Immunology and Inflammation, Neurobiology; Mutation Type: Targeted Mutation ; Collection:

Phenotype: decreased hematocrit [MP:0000208]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| dermatitis [MP:0001194]| decreased body size [MP:0001265]| reduced long term depression [MP:0001475]| anemia [MP:0001577]| abnormal long term depression [MP:0001898]| abnormal glucose homeostasis [MP:0002078]| abnormal T cell differentiation [MP:0002145]| abnormal lymph node morphology [MP:0002339]| abnormal double-positive T cell morphology [MP:0002408]| abnormal CD8-positive [MP:0002436]| alpha-beta cytotoxic T cell morphology [MP:0002461]| increased immunoglobulin level [MP:0002493]| increased IgG level [MP:0002494]| increased IgM level [MP:0002722]| abnormal immune system organ morphology [MP:0003008]| enhanced long term potentiation [MP:0003306]| small intestinal inflammation [MP:0003944]| abnormal T cell subpopulation ratio [MP:0004165]| abnormal lateral geniculate nucleus morphology [MP:0004753]| abnormal miniature excitatory postsynaptic currents [MP:0004792]| abnormal synaptic vesicle number [MP:0005026]| decreased susceptibility to parasitic infection [MP:0005078]| abnormal cytotoxic T cell physiology [MP:0005348]| increased T cell proliferation [MP:0005638]| hemochromatosis [MP:0008071]| absent B cells [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008077]| decreased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008079]| abnormal CD8-positive [MP:0008080]| alpha-beta T cell number [MP:0008097]| increased CD8-positive [MP:0008101]| alpha-beta T cell number [MP:0008346]| decreased CD8-positive [MP:0008350]| alpha-beta T cell number [MP:0008535]| abnormal CD8-positive [MP:0008560]| alpha-beta T cell differentiation [MP:0008571]| increased plasma cell number [MP:0008696]| lymph node hypoplasia [MP:0008700]| increased gamma-delta T cell number [MP:0008751]| increased gamma-delta intraepithelial T cell number [MP:0008752]| enlarged lateral ventricles [MP:0009538]| reduced long term depression [MP:0001475]| abnormal long term depression [MP:0001898]| increased tumor incidence [MP:0002020]| enhanced long term potentiation [MP:0003008]| abnormal lateral geniculate nucleus morphology [MP:0004165]| abnormal miniature excitatory postsynaptic currents [MP:0004753]| abnormal synaptic vesicle number [MP:0004792]| increased lung tumor incidence [MP:0008014]| enlarged lateral ventricles [MP:0008535]| abnormal synaptic bouton morphology [MP:0008571]| increased uterus tumor incidence [MP:0009222]| abnormal synapse morphology [MP:0009538]| increased gastrointestinal tumor incidence [MP:0010279]| increased mammary gland tumor incidence [MP:0010299]| increased skin tumor incidence [MP:0010300]

Affected Gene: |B2m||Tap1

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Catalog Number: 032245-UCD

Background: Targeted Mutation

Database: Mutant Mouse Resource and Research Center (MMRRC)

Database Abbreviation: MMRRC

Source References: PMID:11118151, PMID:17420446, PMID:9548460, PMID:2685607, PMID:8643655

Alternate IDs: MMRRC_32245-UCD, MMRRC_032245, MMRRC_32245

Organism Name: B6.Cg-B2m^tm1Jae Tap1^tm1Hpl/Mmucd

Record Creation Time: 2023-03-07 09:51:27

Record Last Update: 2026-07-25 09:41:30

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No rating or validation information has been found for B6.Cg-B2m^tm1Jae Tap1^tm1Hpl/Mmucd.

Issue
Warning. Researchers have noted that this genotype does not sufficiently model human type 1 diabetes mellitus.

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Data and Source Information

Source: Integrated Animals

Source Database: Mutant Mouse Resource and Research Center (MMRRC)

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