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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=49199
Proper Citation: RRID:MMRRC_049199-UCD
Description: Mus musculus with name C57BL/6N-Prkab1tm1b(KOMP)Wtsi/MbpMmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection: KOMP
Phenotype: increased bone mineral density [MP:0000062]| decreased circulating LDL cholesterol level [MP:0000183]| decreased circulating HDL cholesterol level [MP:0000186]| decreased hematocrit [MP:0000208]| extramedullary hematopoiesis [MP:0000240]| abnormal erythropoiesis [MP:0000245]| echinocytosis [MP:0000256]| enlarged heart [MP:0000274]| schistocytosis [MP:0000314]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| anophthalmia [MP:0001293]| abnormal lens morphology [MP:0001303]| hemolytic anemia [MP:0001585]| abnormal bone marrow morphology [MP:0002397]| abnormal erythrocyte morphology [MP:0002447]| decreased mean corpuscular volume [MP:0002591]| increased mean platelet volume [MP:0002599]| increased heart rate [MP:0002626]| reticulocytosis [MP:0002640]| anisocytosis [MP:0002642]| abnormal retinal vasculature morphology [MP:0002792]| microcytic anemia [MP:0002810]| microcytosis [MP:0002813]| decreased hemoglobin content [MP:0002874]| decreased erythrocyte cell number [MP:0002875]| increased erythroid progenitor cell number [MP:0003135]| abnormal locomotor activation [MP:0003313]| abnormal erythrocyte osmotic lysis [MP:0003657]| decreased lean body mass [MP:0003961]| decreased circulating iron level [MP:0004151]| increased spleen weight [MP:0004952]| decreased T cell number [MP:0005018]| decreased circulating cholesterol level [MP:0005179]| impaired glucose tolerance [MP:0005293]| increased circulating bilirubin level [MP:0005344]| immune system phenotype [MP:0005387]| decreased mean corpuscular hemoglobin [MP:0005562]| decreased mean corpuscular hemoglobin concentration [MP:0005642]| increased glycosylated hemoglobin level [MP:0006353]| decreased CD8-positive [MP:0008079]| alpha-beta T cell number [MP:0008476]| increased spleen red pulp amount [MP:0008805]| decreased circulating amylase level [MP:0008809]| increased spleen iron level [MP:0010025]| decreased total body fat amount [MP:0010067]| increased red blood cell distribution width [MP:0010074]| stomatocytosis [MP:0010097]| abnormal retinal blood vessel morphology [MP:0010177]| acanthocytosis [MP:0010507]| shortened RR interval [MP:0011110]| preweaning lethality [MP:0011178]| incomplete penetrance [MP:0011285]| increased erythroblast number [MP:0011890]| increased circulating erythropoietin level [MP:0011913]| increased circulating ferritin level [MP:0013418]| abnormal reticulocyte cell number [MP:0013435]| increased memory-marker gamma-delta T cell number [MP:0013691]| decreased CD8-positive [MP:0013772]
Affected Gene: Prkab1
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No rating or validation information has been found for C57BL/6N-Prkab1tm1b(KOMP)Wtsi/MbpMmucd.
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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