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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=43538
Proper Citation: RRID:MMRRC_043538-UNC
Description: Mus musculus with name B6.Cg-Cdkn2atm3.1Nesh Tyrc-2J Hrhr/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Cancer, Cell Biology, Dermatology, Hematology, Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal heart looping [MP:0000269]| enlarged pericardium [MP:0000291]| increased cell proliferation [MP:0000351]| decreased cell proliferation [MP:0000352]| loss of eyelid cilia [MP:0000425]| deformed nails [MP:0000580]| abnormal hepatocyte morphology [MP:0000607]| abnormal mammary gland morphology [MP:0000627]| sebaceous gland atrophy [MP:0000649]| telencephalon hypoplasia [MP:0000785]| abnormal skin condition [MP:0001191]| increased sensitivity to skin irradiation [MP:0001203]| decreased sensitivity to skin irradiation [MP:0001204]| wrinkled skin [MP:0001211]| epidermal hyperplasia [MP:0001222]| hyperkeratosis [MP:0001242]| dermal cysts [MP:0001247]| abnormal cornea morphology [MP:0001312]| abnormal eyelid morphology [MP:0001340]| abnormal nursing [MP:0001382]| abnormal coat appearance [MP:0001510]| decreased embryo size [MP:0001698]| edema [MP:0001785]| eye inflammation [MP:0001851]| increased leukemia incidence [MP:0002026]| increased skin papilloma incidence [MP:0002051]| abnormal skin morphology [MP:0002060]| abnormal hair growth [MP:0002073]| premature death [MP:0002083]| abnormal skin pigmentation [MP:0002095]| abnormal neural tube morphology [MP:0002151]| abnormal melanocyte morphology [MP:0002877]| abnormal tumor morphology [MP:0003448]| abnormal physiological neovascularization [MP:0003710]| increased tumor growth/size [MP:0003721]| hairless [MP:0003815]| increased mortality induced by ionizing radiation [MP:0003992]| caudal body truncation [MP:0004073]| increased squamous cell carcinoma incidence [MP:0004207]| increased incidence of tumors by UV-induction [MP:0004501]| decreased incidence of tumors by UV induction [MP:0004504]| absent linear vestibular evoked potential [MP:0004813]| decreased T cell number [MP:0005018]| abnormal dermis reticular layer morphology [MP:0005081]| decreased T cell proliferation [MP:0005095]| blepharitis [MP:0005251]| increased macrophage cell number [MP:0005425]| abnormal skin physiology [MP:0005501]| uveitis [MP:0005515]| small pharyngeal arch [MP:0006346]| decreased birth body size [MP:0009703]| increased skin squamous cell carcinoma incidence [MP:0009704]| increased prostaglandin level [MP:0009814]| decreased prostaglandin level [MP:0009815]| increased skin tumor incidence [MP:0010300]| postnatal lethality [MP:0011086]| incomplete penetrance [MP:0011100]| preweaning lethality [MP:0012022]| complete penetrance [MP:0012431]| increased melanocyte number [MP:0012728]| increased lymphoma incidence [MP:0013392]| absent hair follicle melanin granules [MP:0000394]| abnormal retinal photoreceptor morphology [MP:0001004]| absent skin pigmentation [MP:0001189]| abnormal keratinocyte apoptosis [MP:0001224]| abnormal retina morphology [MP:0001325]| retinal degeneration [MP:0001326]| decreased retinal photoreceptor cell number [MP:0001327]| abnormal vision [MP:0002090]| no abnormal phenotype detected [MP:0002169]| decreased susceptibility to bacterial infection [MP:0002411]| abnormal iridocorneal angle [MP:0004221]| iris synechia [MP:0004222]| absent Schlemm's canal [MP:0004226]| increased cellular sensitivity to ionizing radiation [MP:0004227]| abnormal melanosome morphology [MP:0005075]| absent coat pigmentation [MP:0005171]| abnormal aqueous drainage system morphology [MP:0005198]| abnormal trabecular meshwork morphology [MP:0005203]| abnormal retinal ganglion layer morphology [MP:0005241]| abnormal eye physiology [MP:0005253]| abnormal intraocular pressure [MP:0005257]| ocular albinism [MP:0006159]| decreased circulating interferon-alpha level [MP:0008574]| decreased circulating interferon-beta level [MP:0008576]| abnormal vitamin A metabolism [MP:0011233]| anterior iris synechia [MP:0011481]| decreased a wave amplitude [MP:0012143]| decreased b wave amplitude [MP:0012144]
Affected Gene: |Cdkn2a||
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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