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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41405
Proper Citation: RRID:MMRRC_041405-UCD
Description: Mus musculus with name B6J.Cg-Ikbkgtm1Dln Tnftm1Gkl/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cell Biology, Dermatology, Developmental Biology, Hematology, Immunology and Inflammation, Models for Human Disease, Neurobiology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased bone mineral density [MP:0000062]| abnormal trabecular bone morphology [MP:0000130]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| abnormal Peyer's patch morphology [MP:0000696]| abnormal spermatogenesis [MP:0001156]| decreased body weight [MP:0001262]| abnormal vasodilation [MP:0001613]| abnormal inflammatory response [MP:0001845]| decreased inflammatory response [MP:0001876]| abnormal glucose homeostasis [MP:0002078]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal lymph node B cell domain morphology [MP:0002344]| abnormal spleen marginal sinus morphology [MP:0002363]| abnormal Peyer's patch follicle morphology [MP:0002389]| abnormal Peyer's patch germinal center morphology [MP:0002391]| abnormal Peyer's patch T cell area morphology [MP:0002392]| decreased susceptibility to bacterial infection [MP:0002411]| increased susceptibility to bacterial infection [MP:0002412]| abnormal macrophage physiology [MP:0002451]| decreased circulating triglyceride level [MP:0002644]| oligozoospermia [MP:0002687]| decreased circulating insulin level [MP:0002727]| dilated heart left ventricle [MP:0002753]| abnormal testes secretion [MP:0002782]| colitis [MP:0002816]| abnormal cytokine secretion [MP:0003009]| rheumatoid arthritis [MP:0003561]| oxidative stress [MP:0003674]| abnormal lymphocyte physiology [MP:0003945]| abnormal spermiation [MP:0004182]| decreased incidence of tumors by chemical induction [MP:0004502]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| decreased testis weight [MP:0004852]| abnormal testis physiology [MP:0004884]| increased osteoblast cell number [MP:0004988]| increased lymphocyte cell number [MP:0005013]| increased susceptibility to parasitic infection [MP:0005027]| cachexia [MP:0005150]| abnormal mesenteric lymph node morphology [MP:0005232]| abnormal fat pad morphology [MP:0005334]| decreased susceptibility to autoimmune disorder [MP:0005351]| decreased percent body fat/body weight [MP:0005459]| decreased circulating glucose level [MP:0005560]| decreased ventricle muscle contractility [MP:0005598]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased circulating leptin level [MP:0005668]| decreased Peyer's patch number [MP:0008133]| small Peyer's patches [MP:0008135]| absent follicular dendritic cells [MP:0008201]| abnormal metallophilic macrophage morphology [MP:0008241]| abnormal osteoclast differentiation [MP:0008396]| abnormal spleen primary B follicle morphology [MP:0008471]| abnormal spleen follicular dendritic cell network [MP:0008473]| absent spleen germinal center [MP:0008474]| increased circulating tumor necrosis factor level [MP:0008553]| decreased circulating tumor necrosis factor level [MP:0008554]| increased tumor necrosis factor secretion [MP:0008560]| abnormal chemokine secretion [MP:0008722]| decreased susceptibility to endotoxin shock [MP:0008734]| increased susceptibility to endotoxin shock [MP:0008735]| cecum inflammation [MP:0009481]| decreased keratinocyte proliferation [MP:0009584]| prenatal lethality [MP:0011101]| incomplete penetrance [MP:0013486]| decreased Paneth cell number [MP:0030466]
Affected Gene: Tnf||Ikbkg|
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Issue
Warning. Researchers have noted that this genotype does not sufficiently model human cherubism.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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