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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37588
Proper Citation: RRID:MMRRC_037588-JAX
Description: Mus musculus with name B6.129S4-Sos1tm1.2Rak/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Cancer, Cardiovascular, Developmental Biology, Hematology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal frontal bone morphology [MP:0000107]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| extramedullary hematopoiesis [MP:0000240]| abnormal erythropoiesis [MP:0000245]| abnormal heart morphology [MP:0000266]| heart right ventricle hypertrophy [MP:0000276]| abnormal myocardial fiber morphology [MP:0000278]| abnormal craniofacial morphology [MP:0000428]| enlarged spleen [MP:0000691]| decreased body length [MP:0001258]| decreased body weight [MP:0001262]| decreased body size [MP:0001265]| ocular hypertelorism [MP:0001300]| abnormal cardiovascular system physiology [MP:0001544]| skin edema [MP:0001786]| hemorrhage [MP:0001914]| premature death [MP:0002083]| heart left ventricle hypertrophy [MP:0002625]| cardiac fibrosis [MP:0003141]| increased cardiomyocyte apoptosis [MP:0003222]| abnormal fetal cardiomyocyte proliferation [MP:0003567]| abnormal heart left ventricle morphology [MP:0003921]| enlarged myocardial fiber [MP:0004564]| myocardial fiber degeneration [MP:0004566]| pericardial effusion [MP:0005312]| cardiac interstitial fibrosis [MP:0005608]| aortic valve stenosis [MP:0006117]| abnormal common myeloid progenitor cell morphology [MP:0006410]| increased megakaryocyte cell number [MP:0008254]| increased spleen red pulp amount [MP:0008476]| decreased cranium height [MP:0008525]| ventricular septal defect [MP:0010402]| ostium secundum atrial septal defect [MP:0010405]| thick aortic valve cusps [MP:0010593]| thick interventricular septum [MP:0010724]| embryonic lethality during organogenesis [MP:0011108]| incomplete penetrance [MP:0011109]
Affected Gene: Sos1
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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