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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37398
Proper Citation: RRID:MMRRC_037398-UNC
Description: Mus musculus with name C57BL/6NTac-Il15tm1Imx/TacMmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased monocyte cell number [MP:0000220]| abnormal immune system morphology [MP:0000685]| decreased body weight [MP:0001262]| abnormal immune system physiology [MP:0001790]| altered susceptibility to infection [MP:0001793]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| premature death [MP:0002083]| small lymph nodes [MP:0002217]| abnormal dendritic cell physiology [MP:0002376]| decreased immunoglobulin level [MP:0002460]| abnormal lymphocyte morphology [MP:0002619]| abnormal cytokine secretion [MP:0003009]| abnormal decidualization [MP:0003845]| abnormal uterine artery morphology [MP:0003995]| abnormal CD8-positive [MP:0004392]| alpha-beta T cell physiology [MP:0004794]| increased anti-nuclear antigen antibody level [MP:0004801]| increased susceptibility to systemic lupus erythematosus [MP:0004974]| decreased regulatory T cell number [MP:0005027]| increased susceptibility to parasitic infection [MP:0005070]| impaired natural killer cell mediated cytotoxicity [MP:0005616]| decreased susceptibility to type IV hypersensitivity reaction [MP:0008045]| decreased NK cell number [MP:0008047]| absent uterine NK cells [MP:0008050]| decreased memory T cell number [MP:0008053]| abnormal NK cell differentiation [MP:0008079]| decreased CD8-positive [MP:0008080]| alpha-beta T cell number [MP:0008127]| abnormal CD8-positive [MP:0008363]| alpha-beta T cell differentiation [MP:0008470]| decreased dendritic cell number [MP:0008499]| decreased CD8-positive [MP:0008500]| gamma-delta intraepithelial T cell number [MP:0008501]| abnormal spleen B cell follicle morphology [MP:0008567]| increased IgG1 level [MP:0008664]| increased IgG2a level [MP:0008827]| increased IgG2b level [MP:0009338]| decreased interferon-gamma secretion [MP:0009789]| decreased interleukin-12 secretion [MP:0009791]| abnormal thymus cell ratio [MP:0020519]
Affected Gene: Il15
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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