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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37353
Proper Citation: RRID:MMRRC_037353-MU
Description: Mus musculus with name NOD.Cg-Cd28tm1Mak Ighmtm1Cgn H2h4/HbmMmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection: Mullen
Phenotype: decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| decreased compact bone thickness [MP:0000135]| enlarged heart [MP:0000274]| increased cell proliferation [MP:0000351]| abnormal intestinal epithelium morphology [MP:0000488]| abnormal spleen morphology [MP:0000689]| enlarged lymph nodes [MP:0000702]| abnormal skin condition [MP:0001191]| abnormal cardiovascular system physiology [MP:0001544]| abnormal humoral immune response [MP:0001800]| arrested B cell differentiation [MP:0001802]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| thymus hypoplasia [MP:0001823]| abnormal antigen presentation [MP:0001835]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| heart inflammation [MP:0001853]| myocarditis [MP:0001856]| kidney inflammation [MP:0001859]| abnormal lymphatic vessel morphology [MP:0001879]| premature death [MP:0002083]| abnormal respiratory system physiology [MP:0002133]| abnormal B cell differentiation [MP:0002144]| abnormal spleen marginal sinus morphology [MP:0002363]| abnormal B lymphocyte antigen presentation [MP:0002453]| decreased immunoglobulin level [MP:0002460]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| tubular nephritis [MP:0002704]| increased urine protein level [MP:0002962]| abnormal cytokine secretion [MP:0003009]| cardiac fibrosis [MP:0003141]| thrombocytopenia [MP:0003179]| small intestinal inflammation [MP:0003306]| increased susceptibility to induced arthritis [MP:0003724]| increased autoantibody level [MP:0003725]| abnormal compact bone morphology [MP:0003797]| abnormal PR interval [MP:0003901]| insulitis [MP:0004031]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased spleen weight [MP:0004953]| increased osteoclast cell number [MP:0004984]| increased T cell number [MP:0005015]| decreased B cell number [MP:0005017]| abnormal response to infection [MP:0005025]| increased susceptibility to parasitic infection [MP:0005027]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| cachexia [MP:0005150]| decreased susceptibility to injury [MP:0005166]| abnormal pancreatic islet morphology [MP:0005215]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005559]| increased circulating glucose level [MP:0005616]| decreased susceptibility to type IV hypersensitivity reaction [MP:0006387]| abnormal T cell number [MP:0008071]| absent B cells [MP:0008075]| decreased CD4-positive [MP:0008079]| alpha beta T cell number [MP:0008127]| decreased CD8-positive [MP:0008171]| alpha-beta T cell number [MP:0008201]| decreased dendritic cell number [MP:0008211]| abnormal mature B cell morphology [MP:0008212]| absent follicular dendritic cells [MP:0008213]| decreased mature B cell number [MP:0008240]| absent mature B cells [MP:0008241]| absent immature B cells [MP:0008401]| abnormal spleen marginal zone macrophage morphology [MP:0008470]| abnormal metallophilic macrophage morphology [MP:0008495]| abnormal CD8 positive [MP:0009346]| alpha-beta intraepithelial T cell morphology [MP:0010965]| abnormal spleen B cell follicle morphology [MP:0012431]| abnormal cytokine secretion [MP:0003009]| thyroid inflammation [MP:0003504]| insulitis [MP:0004031]| decreased susceptibility to autoimmune diabetes [MP:0004804]| periinsulitis [MP:0005580]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal esophageal epithelium morphology [MP:0000468]| enlarged thymus [MP:0000709]| increased activated T cell number [MP:0001829]| brain inflammation [MP:0001847]| increased T cell derived lymphoma incidence [MP:0002024]| abnormal T cell differentiation [MP:0002145]| abnormal lymphopoiesis [MP:0002401]| decreased immunoglobulin level [MP:0002460]| abnormal cytokine secretion [MP:0003009]| esophageal inflammation [MP:0003278]| insulitis [MP:0004031]| increased length of allograft survival [MP:0004751]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| abnormal class switch recombination [MP:0004816]| abnormal regulatory T cell physiology [MP:0004946]| decreased regulatory T cell number [MP:0004974]| abnormal T cell clonal deletion [MP:0005002]| increased eosinophil cell number [MP:0005011]| increased susceptibility to parasitic infection [MP:0005027]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased cytotoxic T cell cytolysis [MP:0005079]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005465]| abnormal T-helper 1 physiology [MP:0005466]| abnormal T-helper 2 physiology [MP:0005596]| increased susceptibility to type I hypersensitivity reaction [MP:0005671]| abnormal response to transplant [MP:0006413]| increased T cell apoptosis [MP:0008049]| increased memory T cell number [MP:0008074]| increased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008192]| increased CD8-positive [MP:0008482]| alpha-beta T cell number [MP:0008495]| abnormal germinal center B cell physiology [MP:0008496]| decreased spleen germinal center number [MP:0008497]| decreased IgG1 level [MP:0008500]| decreased IgG2a level [MP:0008566]| decreased IgG2b level [MP:0008567]| increased IgG2a level [MP:0008578]| increased interferon-gamma secretion [MP:0008603]| decreased interferon-gamma secretion [MP:0008687]| decreased circulating interferon-gamma level [MP:0008688]| decreased circulating interleukin-4 level [MP:0008699]| increased interleukin-2 secretion [MP:0008700]| decreased interleukin-2 secretion [MP:0008747]| increased interleukin-4 secretion [MP:0009335]| decreased interleukin-4 secretion [MP:0010268]| abnormal T cell anergy [MP:0010766]
Affected Gene: Cd28||Ighm|||
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No rating or validation information has been found for NOD.Cg-Cd28tm1Mak Ighmtm1Cgn H2h4/HbmMmmh.
Issue
Warning. Researchers have noted that this genotype does not sufficiently model human rheumatoid arthritis.
Issue
Warning. Researchers have noted that this genotype does not sufficiently model human type 1 diabetes mellitus.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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