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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37337
Proper Citation: RRID:MMRRC_037337-MU
Description: Mus musculus with name 129S7-Gnai2tm1Lbi/Mmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: Cancer, Cardiovascular, Cell Biology, Dermatology, Developmental Biology, Diabetes, Endocrine Deficiency, Hematology, Immunology and Inflammation, Metabolism, Models for Human Disease, Neurobiology, Obesity, Reproduction, Research Tools, Sensorineural; Mutation Type: Targeted Mutation ; Collection:
Phenotype: rib fusion [MP:0000154]| abnormal leukocyte cell number [MP:0000217]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| increased granulocyte number [MP:0000322]| abnormal large intestine morphology [MP:0000489]| rectal prolapse [MP:0000493]| abnormal colon morphology [MP:0000495]| intestinal ulcer [MP:0000512]| abnormal liver morphology [MP:0000598]| abnormal immune system morphology [MP:0000685]| increased thymocyte number [MP:0000714]| weakness [MP:0000746]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| cyanosis [MP:0001575]| abnormal digestive system physiology [MP:0001663]| chronic diarrhea [MP:0001665]| postnatal growth retardation [MP:0001732]| abnormal immune system physiology [MP:0001790]| increased inflammatory response [MP:0001846]| respiratory distress [MP:0001954]| premature death [MP:0002083]| abnormal T cell physiology [MP:0002444]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| abnormal eosinophil physiology [MP:0002465]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| increased IgA level [MP:0002495]| megacolon [MP:0002731]| colitis [MP:0002816]| increased heart weight [MP:0002833]| fatigue [MP:0002899]| increased intestinal adenocarcinoma incidence [MP:0002957]| abnormal cytokine secretion [MP:0003009]| peritoneal inflammation [MP:0003303]| large intestinal inflammation [MP:0003304]| abnormal leukocyte adhesion [MP:0003628]| abnormal response/metabolism to endogenous compounds [MP:0003638]| pulmonary edema [MP:0003828]| abnormal large intestine crypts of Lieberkuhn morphology [MP:0004842]| dilated heart [MP:0004937]| increased eosinophil cell number [MP:0005011]| decreased eosinophil cell number [MP:0005012]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| increased susceptibility to parasitic infection [MP:0005027]| ascites [MP:0005324]| increased T cell proliferation [MP:0005348]| increased single-positive T cell number [MP:0008082]| abnormal sternocostal joint morphology [MP:0008148]| increased tumor necrosis factor secretion [MP:0008560]| increased interferon-gamma secretion [MP:0008566]| increased circulating interferon-gamma level [MP:0008577]| increased circulating interleukin-4 level [MP:0008602]| increased circulating interleukin-5 level [MP:0008626]| increased interleukin-1 beta secretion [MP:0008657]| increased interleukin-2 secretion [MP:0008687]| abnormal cytokine level [MP:0008713]| increased physiological sensitivity to xenobiotic [MP:0008873]| decreased physiological sensitivity to xenobiotic [MP:0008874]| decreased birth body size [MP:0009703]| abnormal cellular extravasation [MP:0009858]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011086]| postnatal lethality [MP:0011102]| incomplete penetrance [MP:0011111]
Affected Gene: Gnai2
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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