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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=36310
Proper Citation: RRID:MMRRC_036310-UCD
Description: Mus musculus with name B6.129S4-Atp8b1tm1Nbf/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Cell Biology, Internal/Organ, Metabolism, Models for Human Disease, Sensorineural; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| enlarged liver [MP:0000599]| abnormal liver physiology [MP:0000609]| cholestasis [MP:0000610]| weight loss [MP:0001263]| postnatal growth retardation [MP:0001732]| abnormal cochlear ganglion morphology [MP:0002855]| increased circulating alanine transaminase level [MP:0002941]| increased circulating alkaline phosphatase level [MP:0002968]| increased liver weight [MP:0002981]| bile duct proliferation [MP:0003255]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| degeneration of organ of Corti supporting cells [MP:0004465]| abnormal outer hair cell stereociliary bundle morphology [MP:0004527]| abnormal bile secretion [MP:0004772]| abnormal bile salt level [MP:0004774]| increased bile salt level [MP:0004789]| increased circulating aspartate transaminase level [MP:0005343]| increased circulating bilirubin level [MP:0005344]| abnormal bile salt homeostasis [MP:0005365]| increased sensitivity to induced morbidity/mortality [MP:0009763]| increased susceptibility to weight loss [MP:0010180]| increased or absent threshold for auditory brainstem response [MP:0011967]
Affected Gene: Atp8b1
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Issue
Warning. Researchers have noted that this genotype does not sufficiently model human intrahepatic cholestasis.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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