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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=34309
Proper Citation: RRID:MMRRC_034309-JAX
Description: Mus musculus with name B6;129S2-E2f1tm1Njd/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cancer, Cell Biology, Diabetes, Endocrine Deficiency; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal cartilage morphology [MP:0000163]| abnormal chondrocyte morphology [MP:0000166]| decreased cell proliferation [MP:0000352]| abnormal salivary gland morphology [MP:0000613]| abnormal thyroid gland morphology [MP:0000681]| Leydig cell hyperplasia [MP:0001152]| seminiferous tubule degeneration [MP:0001154]| increased sensitivity to skin irradiation [MP:0001203]| decreased body weight [MP:0001262]| decreased body size [MP:0001265]| increased metastatic potential [MP:0001272]| abnormal circulating insulin level [MP:0001560]| abnormal pancreas morphology [MP:0001944]| increased tumor incidence [MP:0002020]| increased lung adenocarcinoma incidence [MP:0002027]| premature death [MP:0002083]| abnormal gland morphology [MP:0002163]| no abnormal phenotype detected [MP:0002169]| decreased circulating insulin level [MP:0002727]| increased insulin sensitivity [MP:0002891]| increased hemangioma incidence [MP:0002947]| abnormal long bone epiphyseal plate morphology [MP:0003055]| decreased insulin secretion [MP:0003059]| abnormal cell cycle [MP:0003077]| testicular atrophy [MP:0003205]| abnormal parotid gland morphology [MP:0003452]| increased thyroid adenoma incidence [MP:0003496]| abnormal submandibular gland morphology [MP:0003793]| decreased testis weight [MP:0004852]| uterine hemorrhage [MP:0004898]| abnormal pancreatic islet morphology [MP:0005215]| abnormal pancreatic beta cell morphology [MP:0005217]| abnormal exocrine pancreas morphology [MP:0005220]| impaired glucose tolerance [MP:0005293]| decreased circulating glucose level [MP:0005560]| adrenal medulla hyperplasia [MP:0008301]| slow postnatal weight gain [MP:0008489]| increased lung non-small cell carcinoma incidence [MP:0008716]| decreased pancreas weight [MP:0009109]| decreased pancreatic islet number [MP:0009168]| small pancreatic islets [MP:0009172]| increased histiocytic sarcoma incidence [MP:0009321]| decreased total body fat amount [MP:0010025]| increased reproductive system tumor incidence [MP:0010287]| increased pituitary gland tumor incidence [MP:0010320]| neonatal lethality [MP:0011088]| incomplete penetrance [MP:0011091]| prenatal lethality [MP:0011098]| complete penetrance [MP:0011099]| embryonic lethality during organogenesis [MP:0011168]| complete penetrance [MP:0012431]| lethality throughout fetal growth and development [MP:0013440]| complete penetrance [MP:0030016]
Affected Gene: E2f1
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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