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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=30492
Proper Citation: RRID:MMRRC_030492-UNC
Description: Mus musculus with name 129S4-Ctla4tm1Shr Cd28tm1Shr/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection:
Phenotype: enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| autoimmune response [MP:0001844]| myocarditis [MP:0001856]| lung inflammation [MP:0001861]| vasculitis [MP:0001864]| pancreas inflammation [MP:0001869]| salivary gland inflammation [MP:0001870]| premature death [MP:0002083]| abnormal T cell differentiation [MP:0002145]| abnormal T cell physiology [MP:0002444]| joint inflammation [MP:0002933]| abnormal cytokine secretion [MP:0003009]| increased length of allograft survival [MP:0004751]| abnormal regulatory T cell physiology [MP:0004946]| abnormal CD8-positive [MP:0005010]| alpha beta T cell morphology [MP:0005015]| increased T cell number [MP:0005090]| increased double-negative T cell number [MP:0005092]| decreased double-positive T cell number [MP:0005095]| decreased T cell proliferation [MP:0005348]| increased T cell proliferation [MP:0005350]| increased susceptibility to autoimmune disorder [MP:0008037]| abnormal T cell morphology [MP:0008075]| decreased CD4-positive [MP:0008568]| alpha beta T cell number [MP:0008750]| abnormal interleukin secretion [MP:0008826]| abnormal interferon level [MP:0008828]| increased length of allograft survival [MP:0004751]| abnormal CD8-positive [MP:0005010]| alpha beta T cell morphology [MP:0005095]| decreased T cell proliferation [MP:0005350]| increased susceptibility to autoimmune disorder [MP:0008075]| decreased CD4-positive [MP:0008568]| alpha beta T cell number [MP:0008688]| abnormal interleukin secretion [MP:0008750]
Affected Gene: |Ctla4||Cd28
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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