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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=30047
Proper Citation: RRID:MMRRC_030047-UNC
Description: Mus musculus with name STOCK Dclre1ctm1Fwa Prkdctm1Get /Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cell Biology, Hematology, Immunology and Inflammation, Models for Human Disease, Research Tools; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal cell morphology [MP:0000358]| spleen hypoplasia [MP:0000694]| arrested B cell differentiation [MP:0001802]| decreased IgM level [MP:0001806]| thymus hypoplasia [MP:0001823]| arrested T cell differentiation [MP:0001825]| increased cellular sensitivity to gamma-irradiation [MP:0002007]| abnormal B cell differentiation [MP:0002144]| abnormal T cell differentiation [MP:0002145]| small lymph nodes [MP:0002217]| increased double-negative T cell number [MP:0005090]| increased double-positive T cell number [MP:0005091]| abnormal T cell number [MP:0006387]| increased NK cell number [MP:0008044]| decreased single-positive T cell number [MP:0008083]| decreased spleen white pulp amount [MP:0008479]| abnormal T cell receptor alpha chain V-J recombination [MP:0008756]| abnormal T cell receptor beta chain V(D)J recombination [MP:0008758]| abnormal T cell receptor delta chain V(D)J recombination [MP:0008759]| abnormal immunoglobulin heavy chain V(D)J recombination [MP:0008760]| abnormal immunoglobulin light chain V-J recombination [MP:0008761]| abnormal thymus corticomedullary boundary morphology [MP:0009543]| spleen hypoplasia [MP:0000694]| decreased thymocyte number [MP:0000715]| arrested B cell differentiation [MP:0001802]| arrested T cell differentiation [MP:0001825]| increased cellular sensitivity to gamma-irradiation [MP:0002007]| induced chromosome breakage [MP:0004030]| increased cellular sensitivity to ionizing radiation [MP:0004227]| decreased double-positive T cell number [MP:0005092]| absent B cells [MP:0008071]| decreased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD8-positive [MP:0008213]| alpha-beta T cell number [MP:0008758]| absent immature B cells [MP:0008866]
Affected Gene: |Dclre1c||Prkdc
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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