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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=11791
Proper Citation: RRID:MMRRC_011791-MU
Description: Mus musculus with name 129S4/SvJae-Cd80tm1Shr Cd86tm1Shr Ctla4tm1Shr/Mmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection:
Phenotype: decreased cell proliferation [MP:0000352]| abnormal spleen morphology [MP:0000689]| decreased IgG level [MP:0001805]| brain inflammation [MP:0001847]| abnormal lymph node B cell domain morphology [MP:0002344]| abnormal T cell physiology [MP:0002444]| abnormal immunoglobulin level [MP:0002490]| increased IgM level [MP:0002494]| abnormal cytokine secretion [MP:0003009]| insulitis [MP:0004031]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased regulatory T cell number [MP:0004974]| decreased double-positive T cell number [MP:0005092]| decreased B cell proliferation [MP:0005093]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005623]| abnormal meninges morphology [MP:0006387]| abnormal T cell number [MP:0008495]| decreased IgG1 level [MP:0008496]| decreased IgG2a level [MP:0008502]| increased IgG3 level [MP:0008560]| increased tumor necrosis factor secretion [MP:0008566]| increased interferon-gamma secretion [MP:0008688]| decreased interleukin-2 secretion [MP:0009023]| paresis [MP:0000754]| hindlimb paralysis [MP:0000755]| demyelination [MP:0000921]| abnormal dorsal root ganglion morphology [MP:0000961]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| brain inflammation [MP:0001847]| muscular atrophy [MP:0002269]| abnormal nervous system morphology [MP:0003632]| increased autoantibody level [MP:0003725]| abnormal myelin sheath morphology [MP:0003871]| abnormal ventral spinal root morphology [MP:0003993]| abnormal dorsal spinal root morphology [MP:0003994]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased regulatory T cell number [MP:0004974]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| abnormal action potential [MP:0005402]| abnormal nerve conduction [MP:0005403]| absent spleen germinal center [MP:0008474]| increased tumor necrosis factor secretion [MP:0008560]| decreased tumor necrosis factor secretion [MP:0008561]| increased interferon-gamma secretion [MP:0008566]| decreased interleukin-12 secretion [MP:0008664]| decreased nerve conduction velocity [MP:0008814]| decreased grip strength [MP:0010053]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| autoimmune response [MP:0001844]| myocarditis [MP:0001856]| lung inflammation [MP:0001861]| vasculitis [MP:0001864]| pancreas inflammation [MP:0001869]| salivary gland inflammation [MP:0001870]| premature death [MP:0002083]| abnormal T cell differentiation [MP:0002145]| abnormal T cell physiology [MP:0002444]| joint inflammation [MP:0002933]| abnormal cytokine secretion [MP:0003009]| increased length of allograft survival [MP:0004751]| abnormal regulatory T cell physiology [MP:0004946]| abnormal CD8-positive [MP:0005010]| alpha beta T cell morphology [MP:0005015]| increased T cell number [MP:0005090]| increased double-negative T cell number [MP:0005092]| decreased double-positive T cell number [MP:0005095]| decreased T cell proliferation [MP:0005348]| increased T cell proliferation [MP:0005350]| increased susceptibility to autoimmune disorder [MP:0008037]| abnormal T cell morphology [MP:0008075]| decreased CD4-positive [MP:0008568]| alpha beta T cell number [MP:0008750]| abnormal interleukin secretion [MP:0008826]| abnormal interferon level [MP:0008828]
Affected Gene: |Cd80||Cd86||Ctla4
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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