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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=11171
Proper Citation: RRID:MMRRC_011171-UNC
Description: Mus musculus with name STOCK Nos2tm1Mrl Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation, Models for Human Disease, Neurobiology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased white adipose tissue amount [MP:0000008]| increased bone mineral density [MP:0000062]| abnormal trabecular bone morphology [MP:0000130]| increased circulating LDL cholesterol level [MP:0000182]| abnormal circulating glucose level [MP:0000188]| abnormal circulating serum albumin level [MP:0000199]| hypertension [MP:0000231]| decreased digestive secretion [MP:0000505]| abnormal uterus morphology [MP:0001120]| increased body weight [MP:0001260]| polydipsia [MP:0001426]| dehydration [MP:0001429]| abnormal skeleton physiology [MP:0001533]| abnormal osteoclast physiology [MP:0001541]| abnormal cardiovascular system physiology [MP:0001544]| increased circulating triglyceride level [MP:0001552]| irregular heartbeat [MP:0001636]| abnormal digestion [MP:0001664]| polyuria [MP:0001762]| abnormal homeostasis [MP:0001764]| abnormal immune system physiology [MP:0001790]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| increased inflammatory response [MP:0001846]| pancreas inflammation [MP:0001869]| abnormal mammary gland physiology [MP:0001881]| reduced fertility [MP:0001921]| decreased litter size [MP:0001935]| abnormal motor capabilities/coordination/movement [MP:0002066]| abnormal sensory capabilities/reflexes/nociception [MP:0002067]| abnormal glucose homeostasis [MP:0002078]| premature death [MP:0002083]| abnormal cardiovascular system morphology [MP:0002127]| abnormal blood circulation [MP:0002128]| abnormal kidney physiology [MP:0002136]| increased susceptibility to bacterial infection [MP:0002412]| abnormal macrophage physiology [MP:0002451]| abnormal immunoglobulin level [MP:0002490]| abnormal eosinophil cell number [MP:0002602]| abnormal vitreous body morphology [MP:0002699]| abnormal thermal nociception [MP:0002733]| increased systemic arterial blood pressure [MP:0002842]| increased growth rate [MP:0002865]| increased insulin sensitivity [MP:0002891]| abnormal bone mineralization [MP:0002896]| delayed wound healing [MP:0002908]| thick ventricular wall [MP:0002953]| increased circulating alkaline phosphatase level [MP:0002968]| abnormal cardiac muscle contractility [MP:0002972]| decreased urine osmolality [MP:0002988]| abnormal bone healing [MP:0002999]| increased myocardial infarction size [MP:0003037]| allodynia [MP:0003177]| neuron degeneration [MP:0003224]| liver fibrosis [MP:0003333]| abnormal bone structure [MP:0003795]| enlarged stomach [MP:0003883]| abnormal tooth hard tissue morphology [MP:0003930]| abnormal hormone level [MP:0003953]| abnormal nitric oxide homeostasis [MP:0003957]| abnormal adrenocorticotropin level [MP:0003966]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| abnormal uterine artery morphology [MP:0003995]| abnormal vascular endothelial cell physiology [MP:0004003]| decreased susceptibility to kidney reperfusion injury [MP:0004042]| abnormal coronary artery morphology [MP:0004111]| increased renal tubule apoptosis [MP:0004153]| renal tubular necrosis [MP:0004154]| abnormal myocardial fiber physiology [MP:0004215]| abnormal peripheral nervous system regeneration [MP:0004220]| increased length of allograft survival [MP:0004751]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| increased mean systemic arterial blood pressure [MP:0004875]| abnormal vascular wound healing [MP:0004883]| decreased adiponectin level [MP:0004893]| abnormal osteoclast morphology [MP:0004982]| increased osteoclast cell number [MP:0004984]| decreased osteoclast cell number [MP:0004985]| decreased eosinophil cell number [MP:0005012]| abnormal response to infection [MP:0005025]| increased circulating prolactin level [MP:0005124]| decreased cardiac muscle contractility [MP:0005140]| increased circulating cholesterol level [MP:0005178]| abnormal circulating estradiol level [MP:0005183]| glomerulosclerosis [MP:0005264]| improved glucose tolerance [MP:0005292]| abnormal heart ventricle morphology [MP:0005294]| abnormal response to tactile stimuli [MP:0005316]| abnormal renal glomerulus morphology [MP:0005325]| decreased heart rate [MP:0005333]| atherosclerotic lesions [MP:0005338]| increased circulating creatinine level [MP:0005553]| increased blood urea nitrogen level [MP:0005565]| increased renin activity [MP:0005582]| decreased cerebral infarction size [MP:0006058]| congestive heart failure [MP:0006138]| abnormal atrioventricular node conduction [MP:0006141]| increased systemic arterial systolic blood pressure [MP:0006144]| abnormal involution of the mammary gland [MP:0006271]| decreased urine sodium level [MP:0006317]| intestine polyps [MP:0008011]| abnormal osteoclast differentiation [MP:0008396]| increased IgG2a level [MP:0008500]| increased interferon-gamma secretion [MP:0008566]| decreased susceptibility to endotoxin shock [MP:0008734]| decreased survivor rate [MP:0008770]| abnormal heart ventricle pressure [MP:0008775]| increased blood osmolality [MP:0008997]| prolonged diestrus [MP:0009011]| abnormal platelet aggregation [MP:0009548]| abnormal blood homeostasis [MP:0009642]| abnormal urine homeostasis [MP:0009643]| abnormal induced retinal neovascularization [MP:0009660]| increased prostaglandin level [MP:0009814]| visceral vascular congestion [MP:0010017]| pulmonary vascular congestion [MP:0010018]| liver vascular congestion [MP:0010019]| abnormal heart electrocardiography waveform feature [MP:0010508]| abnormal heart right ventricle pressure [MP:0010755]| pyloric sphincter hypertrophy [MP:0010781]| increased bone volume [MP:0010875]| increased compact bone mass [MP:0010961]| glomerular capillary thrombosis [MP:0011508]| decreased urine prostaglandin level [MP:0011564]| decreased urine nitrite level [MP:0011742]| perivascular fibrosis [MP:0011749]| increased food intake [MP:0011939]| hyperlactation [MP:0013717]| increased circulating LDL cholesterol level [MP:0000182]| amyloidosis [MP:0000604]| abnormal forebrain morphology [MP:0000783]| abnormal hindbrain morphology [MP:0000841]| small cerebellum [MP:0000852]| abnormal cerebellar foliation [MP:0000857]| decreased body weight [MP:0001262]| decreased anxiety-related response [MP:0001364]| hyperactivity [MP:0001399]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| decreased grooming behavior [MP:0001442]| abnormal object recognition memory [MP:0001458]| abnormal spatial learning [MP:0001463]| reduced long term potentiation [MP:0001473]| hunched posture [MP:0001505]| abnormal lipid level [MP:0001547]| impaired synaptic plasticity [MP:0001900]| reduced NMDA-mediated synaptic currents [MP:0001902]| intracranial hemorrhage [MP:0001915]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| abnormal blood circulation [MP:0002128]| abnormal astrocyte morphology [MP:0002182]| gliosis [MP:0002183]| neurodegeneration [MP:0002229]| increased thigmotaxis [MP:0002797]| abnormal eye blink conditioning behavior [MP:0002807]| abnormal neuron morphology [MP:0002882]| abnormal excitatory postsynaptic potential [MP:0002912]| decreased post-tetanic potentiation [MP:0002922]| neurofibrillary tangles [MP:0003214]| neuron degeneration [MP:0003224]| loss of hippocampal neurons [MP:0003240]| amyloid beta deposits [MP:0003329]| astrocytosis [MP:0003354]| abnormal microglial cell physiology [MP:0003691]| tau protein deposits [MP:0004250]| cerebral amyloid angiopathy [MP:0004254]| abnormal miniature excitatory postsynaptic currents [MP:0004753]| abnormal neuron physiology [MP:0004811]| increased circulating cholesterol level [MP:0005178]| abnormal eye physiology [MP:0005253]| abnormal renal glomerulus morphology [MP:0005325]| abnormal hippocampus CA3 region morphology [MP:0008267]| abnormal subiculum morphology [MP:0008287]| abnormal spatial working memory [MP:0008428]| abnormal short term spatial reference memory [MP:0008431]| abnormal long term spatial reference memory [MP:0008432]| microgliosis [MP:0008918]| decreased neuron number [MP:0008948]| paraparesis [MP:0009434]| enhanced contextual conditioning behavior [MP:0009453]| abnormal synapse morphology [MP:0009538]| decreased brain zinc level [MP:0009617]| increased brain zinc level [MP:0009618]| reduced AMPA-mediated synaptic currents [MP:0011003]| abnormal catecholamine level [MP:0011479]| decreased vocalization [MP:0020351]
Affected Gene: |Nos2|APP||Prnp|PSEN1|THY1|
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No rating or validation information has been found for STOCK Nos2tm1Mrl Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc.
No alerts have been found for STOCK Nos2tm1Mrl Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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