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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=11170
Proper Citation: RRID:MMRRC_011170-UNC
Description: Mus musculus with name STOCK Nos2+ Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation, Models for Human Disease, Neurobiology; Mutation Type: Transgenic ; Collection:
Phenotype: increased circulating LDL cholesterol level [MP:0000182]| amyloidosis [MP:0000604]| abnormal forebrain morphology [MP:0000783]| abnormal hindbrain morphology [MP:0000841]| small cerebellum [MP:0000852]| abnormal cerebellar foliation [MP:0000857]| decreased body weight [MP:0001262]| decreased anxiety-related response [MP:0001364]| hyperactivity [MP:0001399]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| decreased grooming behavior [MP:0001442]| abnormal object recognition memory [MP:0001458]| abnormal spatial learning [MP:0001463]| reduced long term potentiation [MP:0001473]| hunched posture [MP:0001505]| abnormal lipid level [MP:0001547]| impaired synaptic plasticity [MP:0001900]| reduced NMDA-mediated synaptic currents [MP:0001902]| intracranial hemorrhage [MP:0001915]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| abnormal blood circulation [MP:0002128]| abnormal astrocyte morphology [MP:0002182]| gliosis [MP:0002183]| neurodegeneration [MP:0002229]| increased thigmotaxis [MP:0002797]| abnormal eye blink conditioning behavior [MP:0002807]| abnormal neuron morphology [MP:0002882]| abnormal excitatory postsynaptic potential [MP:0002912]| decreased post-tetanic potentiation [MP:0002922]| neurofibrillary tangles [MP:0003214]| neuron degeneration [MP:0003224]| loss of hippocampal neurons [MP:0003240]| amyloid beta deposits [MP:0003329]| astrocytosis [MP:0003354]| abnormal microglial cell physiology [MP:0003691]| tau protein deposits [MP:0004250]| cerebral amyloid angiopathy [MP:0004254]| abnormal miniature excitatory postsynaptic currents [MP:0004753]| abnormal neuron physiology [MP:0004811]| increased circulating cholesterol level [MP:0005178]| abnormal eye physiology [MP:0005253]| abnormal renal glomerulus morphology [MP:0005325]| abnormal hippocampus CA3 region morphology [MP:0008267]| abnormal subiculum morphology [MP:0008287]| abnormal spatial working memory [MP:0008428]| abnormal short term spatial reference memory [MP:0008431]| abnormal long term spatial reference memory [MP:0008432]| microgliosis [MP:0008918]| decreased neuron number [MP:0008948]| paraparesis [MP:0009434]| enhanced contextual conditioning behavior [MP:0009453]| abnormal synapse morphology [MP:0009538]| decreased brain zinc level [MP:0009617]| increased brain zinc level [MP:0009618]| reduced AMPA-mediated synaptic currents [MP:0011003]| abnormal catecholamine level [MP:0011479]| decreased vocalization [MP:0020351]
Affected Gene: |APP|Prnp|PSEN1||THY1|Nos2|
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No rating or validation information has been found for STOCK Nos2+ Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc.
No alerts have been found for STOCK Nos2+ Tg(APPSWE)2576Kha Tg(Thy1-PSEN1*A246E)16-3Sqn/Mmnc.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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