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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=10624
Proper Citation: RRID:MMRRC_010624-UNC
Description: Mus musculus with name 129S4/SvJae-Cd86tm1Shr/Mmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection:
Phenotype: paresis [MP:0000754]| hindlimb paralysis [MP:0000755]| demyelination [MP:0000921]| abnormal dorsal root ganglion morphology [MP:0000961]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| brain inflammation [MP:0001847]| muscular atrophy [MP:0002269]| abnormal nervous system morphology [MP:0003632]| increased autoantibody level [MP:0003725]| abnormal myelin sheath morphology [MP:0003871]| abnormal ventral spinal root morphology [MP:0003993]| abnormal dorsal spinal root morphology [MP:0003994]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased regulatory T cell number [MP:0004974]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| abnormal action potential [MP:0005402]| abnormal nerve conduction [MP:0005403]| absent spleen germinal center [MP:0008474]| increased tumor necrosis factor secretion [MP:0008560]| decreased tumor necrosis factor secretion [MP:0008561]| increased interferon-gamma secretion [MP:0008566]| decreased interleukin-12 secretion [MP:0008664]| decreased nerve conduction velocity [MP:0008814]| decreased grip strength [MP:0010053]
Affected Gene: Cd86
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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