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URL: http://eagle-i.itmat.upenn.edu/i/0000013b-7127-463d-83a0-df0880000000
Proper Citation: Penn Gene Targeting Service (RRID:SCR_010013)
Description: The Penn Gene Targeting Service (PGT) is run by the Penn Gene Targeting Core and Laboratory in collaboration with two other Penn Cores (DNA Sequencing Facility and the Transgenic and Chimeric Mouse Facility) and has the capability to generate from scratch almost any type of genetically modified mouse. This includes complete knockout of any gene, tissue-specific and/or drug-inducible knockout of any gene, targeted mutagenesis of any region of any gene (knockin), tissue-specific activation of an endogenous gene using loxP flanked stop cassettes, and tissue-specific and/or drug-inducible transgene expression from defined loci. For details regarding services and prices please consult the PGT home page of the Department of Genetics and/or directly contact Dr. Tobias Raabe. The Client lab does not need to be involved in any experimental step and only needs to breed the resulting mice. However, if desired, participation of the client lab in almost any experimental step is possible. PGT has an outstanding record of germ line transmission and so far over 32 targeted mice - more than 12 in the desirable C57BL6 background - have been made, starting either with molecular design and construction of the targeting vector or with electroporation of an existing targeting vector into ES cells.
Resource Type: access service resource, core facility, service resource
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