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Resource Name
DART - Drug Adverse Reaction Targets
RRID:SCR_007041 RRID Copied      
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DART - Drug Adverse Reaction Targets (RRID:SCR_007041)
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Resource Information

URL: http://xin.cz3.nus.edu.sg/group/drt/dart.asp

Proper Citation: DART - Drug Adverse Reaction Targets (RRID:SCR_007041)

Description: Database that provides comprehensive information about adverse effect targets of drugs described in the literature, including information about known drug adverse reaction targets, functions and properties. Moreover, proteins involved in adverse effect targets of chemicals not yet confirmed as adverse drug reaction (ADR) targets are also included as potential targets. Associated references are also included. This database gives physiological function of each target, binding drugs / agonists / antagonists / activators / inhibitors, IC(50) values of the inhibitors, corresponding adverse effects, and type of ADR induced by drug binding to a target. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3-dimensional structure, function, and nomenclature of each target along with drug/ligand binding properties, and related literature. Each entry can be retrieved through multiple search methods including target name, target physiological function, adverse effect, ligand name, and biological pathways. A special page is provided for contribution of new or additional information. Function for ADR-target prediction by SVMDART: Submit protein primary sequence for ADR-related protein prediction.

Abbreviations: DART

Resource Type: storage service resource, data or information resource, service resource, database, data repository

Defining Citation: PMID:12862503

Keywords: drug, drug target, evaluation, adverse drug reaction, adverse reaction, agonist, antagonist, binding, ic value, inhibitor, ligand binding property, ligand, physiological function, protein prediction, protein, protein target, target, type, toxicity, data analysis service, toxic

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