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URL: http://bioinformatics.biol.uoa.gr/human_gpdb/
Proper Citation: Human-gpDB (RRID:SCR_006223)
Description: A publicly accessible, relational database of human G-Proteins and their interactions with human GPCRs and Effectors. Advanced data integration techniques make Human-gpDB very rich in context since all of the bioentities are linked to a rich variety of external data sources. High quality visualization methods make the networks more informative and the extraction of information easier. Human-gpDB is currently a very useful tool for drug targeting investigation. The sequences of G-Proteins and GPCRs are classified according to a hierarchy of different classes, families and sub-families, whereas the Effectors sequences are classified in families, subfamilies and types, based on extensive literature search. The classification of GPCRs follows the IUPHAR classification, while the Effectors classification is a unique feature and is based on their function. The database currently holds information about 713 human GPCRs, 36 human G-Proteins and 99 human Effectors. The collection of the information about the interactions between these molecules was done manually and the current status of Human-gpDB reveals information about 1663 connections between GPCRs and G-Proteins and 1618 connections between G-Proteins and Effectors.
Abbreviations: Human-gpDB
Synonyms: Human-gpDB: A database of human GPCRs G-proteins Effectors and their interactions
Resource Type: analysis service resource, production service resource, data or information resource, data analysis service, database, service resource
Defining Citation: PMID:20689020
Keywords: g-protein coupled receptor, g-protein, effector, interaction, visualization, data integration
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University of Athens Biophysics and Bioinformatics Laboratory |
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