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URL: http://web.stanford.edu/group/nusselab/cgi-bin/wnt/
Proper Citation: Wnt Database (RRID:SCR_006020)
Description: Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling.As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to beta-catenin , which then enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes. Protein sequence databases, Databases of individual protein families, Metabolic and Signaling Pathways, Protein-protein interactions
Synonyms: Wnt Database
Resource Type: data or information resource, database
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