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URL: http://bmsr.usc.edu/software/eons/
Proper Citation: EONS (RRID:SCR_002979)
Description: Modeling platform to study the basic interactions between synaptic elements that allows the user to study qualitatively, and also quantitatively the relative contributions of diverse mechanisms underlying synaptic efficacy: the relevance of each and every element that comprises a synapse, the interactions between these components and their subcellular distribution, as well as the influence of synaptic geometry (presynaptic terminal, cleft and postsynaptic density). This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more. EONS is a parametric model of a generic glutamatergic synapse that takes into account pre-synaptic mechanisms, such as calcium buffering and diffusion, neurotransmitter release, diffusion and uptake in the cleft, and postsynaptic elements, such as ionotropic AMPA and NMDA receptors, their distribution and synaptic geometry, as well as metabotropic glutamate receptors. There are no complicated equations to write: all the models are predefined. This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry. System Requirements: EONS V1.2 is a Windows program but can be also successfully installed and run on Mac and Linux.
Abbreviations: EONS
Synonyms: Elementary Objects of the Nervous System, EONS-The integrated synaptic modeling platform, EONS (Elementary Objects of the Nervous System)
Resource Type: software application, software resource, simulation software
Defining Citation: PMID:17946227
Keywords: synapse, geometry, distribution hypothesis, 2d, synaptic modeling, synaptic, modeling, neuron, nervous system, presynaptic, postsynaptic, electromicrograph, animation, simulation, calcium channel, synaptic cleft, excitatory postsynaptic potential, potassium channel, computational neuroscience, java, macos, microsoft, windows, windows xp
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