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URL: http://mendel.stanford.edu/SidowLab/downloads/gerp/
Proper Citation: GERP (RRID:SCR_000563)
Description: Software that identifies constrained elements in multiple alignments by quantifying substitution deficits. These deficits represent substitutions that would have occurred if the element were neutral DNA, but did not occur because the element has been under functional constraint. We refer to these deficits as Rejected Substitutions. Rejected substitutions are a natural measure of constraint that reflects the strength of past purifying selection on the element. GERP estimates constraint for each alignment column; elements are identified as excess aggregations of constrained columns. A false-positive rate (which is user-settable) is calculated using "shuffled" alignments in which the order of columns is randomized.
Abbreviations: GERP
Synonyms: Genomic Evolutionary Rate Profiling, GERP++, Genomic Evolutionary Rate Profiling: GERP, GERP2
Resource Type: software resource
Defining Citation: PMID:15965027, PMID:21152010
Keywords: genomic, evolution, rate profiling
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