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URL: http://www.grissom.gr/stranger/
Proper Citation: StRAnGER (RRID:SCR_004247)
Description: StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER''''s algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context. Platform: Online tool
Abbreviations: StRAnGER
Synonyms: Statistical Ranking of ANotated Genomic Experimental Results
Resource Type: data processing software, software resource, data analysis software, software application
Defining Citation: PMID:21293737
Keywords: controlled vocabulary, functional analysis, genomics, annotation, visualization, statistical analysis, term enrichment, ontology or annotation visualization
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