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URL: https://web.expasy.org/cellosaurus/CVCL_A7ZQ
Proper Citation: RRID:CVCL_A7ZQ
Description: Cell line A549-Dual hACE2-TMPRSS2 is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Male
Disease: Lung adenocarcinoma
Comments: Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=a549d-cov2r)., Characteristics: Ideal for studying SARS-CoV-2 viral entry into host cells, the viral RNA sensing pathway, as well as screening small molecule inhibitors and neutralizing antibodies. These cells are permissive to infection by SARS-CoV-2 Spike-pseudotyped viral particles (InvivoGen=a549d-cov2r)., Population: Caucasian., Group: SARS-CoV-2 research cell line.
Category: Cancer cell line
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Source: Cellosaurus
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