Displaying results 1 - 20 out of 59 total results.
THIS RESOURCE IS NO LONGER IN SERVICE, documented on December 20, 2013.\\nA freely downloadable interactive diagram containing existing knowledge of hippocampal - parahippocampal connections in which any connection can be turned on or off at the level of cortical layers. It includes references for each connection. \\nProject Goals:\\n* To provide an overview of all known anatomical projections of the rat hippocampal - parahippocampal network.\\n* To provide a graphical interface with which users can turn on or off any connections at regional level down to the level of cortical layers.\\n* To make it easy to find references for a particular projection. \\nAlmost 1600 connections in the rat hippocampal - parahippocampal region are displayed.
A software package for automatic segmentation of hippocampal subfields in magnetic resonance imges. Given a pair of T1-weighted and T2-weighted images (the latter acquired using a protocol tuned for hippocampus imaging), ASHS will automatically label main subfields of the hippocampus, and some extra-hippocampal structures, using multi-atlas segmentation. The main method is described in the Yushkevich et al. 2011 Neuroimage paper (http://tinyurl.com/cffrp3p).\\n* execution requires: Advanced Normalization Tools, FSL
Open-source turnkey software for automatic hippocampus segmentation. Its primary use is for delineating hippocampus in T1-weighted MRI images. AHEAD is developed by Jung W. Suh, Hongzhi Wang, Sandhitsu Das, Brian Avants, Philip Cook, John Pluta and Paul Yushkevich, and colleagues at the Penn Image Computing and Science Laboratory (PICSL) at the University of Pennsylvania.
An interactive reference atlas providing a systematic overview of cyto- and chemoarchectonical features of the hippocampus proper, fasciola, and associated parahippocampal cortices. This atlas system has been developed to serve the need to integrate detailed descriptions of structures and criteria defining boundaries and atlas images in which the underlying histological features can be explored. \\nFeatures\\n* Alphabetical and hierarchical overview of 18 hippocampal structures\\n* Detailed, illustrated descriptions of 63 boundaries\\n* Interactive image repository with ~100 coronal histological images stained for NeuN, calbindin, and parvalbumin\\n* Triple image viewer in which differently stained neighboring sections can be interactively compared\\n* Graphical overlay of substructures based on described boundary criteria\\n* Bidirectional links between structure descriptions and image repository\\nThe atlas is based on histological material from an adult Long Evans rat, stained for NeuN, calbindin, and parvalbumin.\\nThe system is intended for researchers working in the field, as well as students interested in this brain region. The atlas is accessed through the structure index or image viewer. Re-use of data from this repository is allowed provided that reference is given to the publication.
This dataset contains T1-weighted MR images of 50 subjects, 40 of whom are patients with temporal lobe epilepsy and 10 are nonepileptic subjects. Hippocampus labels are provided for 25 subjects for training. The users may submit their segmentation outcomes for the remaining 25 testing images to get a table of segmentation metrics.
Atlas of segmented and normalized high-resolution postmortem MRI of the human hippocampus. Additional data (raw images) is available through the SCM link. It requires knowing how to use CVS.
Data files for a high resolution three dimensional (3D) structure of the rat hippocampus reconstructed from histological sections. The data files (supplementary data for Ropireddy et al., Neurosci., 2012 Mar 15;205:91-111) are being shared on the Windows Live cloud space provided by Microsoft. Downloadable data files include the Nissl histological images, the hippocampus layer tracings that can be visualized alone or superimposed to the corresponding Nissl images, the voxel database coordinates, and the surface rendering VRML files.\\n* Hippocampus Nissl Images: The high resolution histological Nissl images obtained at 16 micrometer inter-slice distance for the Long-Evans rat hippocampus can be downloaded or directly viewed in a browser. This dataset consists of 230 jpeg images that cover the hippocampus from rostral to caudal poles. This image dataset is uploaded in seven parts as rar files.\\n* Hippocampus Layer Tracings: The seven hippocampus layers 'ML, 'GC', 'HILUS' in DG and 'LM', 'RAD', 'PC', 'OR' in CA were segmented (traced) using the Reconstruct tool which can be downloaded from Synapse web. This tool outputs all the tracings for each image in XML format. The XML tracing files for all these seven layers for each of the above Nissl images are zipped into one file and can be downloaded. \\n* Hippocampus VoxelDB: The 3D hippocampus reconstructed is volumetrically transformed into 16 micrometer sized voxels for all the seven layers. Each voxel is reported according to multiple coordinate systems, namely in Cartesian, along the natural hippocampal dimensions, and in reference to the canonical brain planes. The voxel database file is created in ascii format. The single voxel database file was split into three rar archive files. Please note that the three rar archive files should be downloaded and decompressed in a single directory in order to obtain the single voxel data file (Hippocampus-VoxelDB.txt).\\n* 3D Surface Renderings: This is a rar archive file with a single VRML file containing the surface rendering of DG and CA layers. This VRML file can be opened and visualized in any VRML viewer, e.g. the open source software view3dscene.\\n* 3D Hippocampus Movie: This movie contains visualization of the 3D surface renderings of CA (blue) and DG (red) inner and outer boundaries; neuronal embeddings of DG granule and CA pyramidal dendritic arbors; potential synapses between CA3b interneuron axon and pyramidal dendrite, and between CA2 pyramidal axon and CA pyramidal dendrites.
THIS RESOURCE IS NO LONGER IN SERVICE, documented on January 29, 2013.\\nSupplemental data for the paper Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice, by Vytautas P. Bindokas, Chong C. Lee, William F. Colmers, and Richard J. Miller that appears in the Journal of Neuroscience June 15, 1998.\\nYou can view digital movies of changes in fluorescence intensity by clicking on the title of interest.
The long-term goals of my research are to understand the relationship between neuronal structure and function, and to elucidate the factors that affect neuronal morphology and function over the lifespan of the mammal. Currently we are examining 1) the effects of synaptic activity on neuronal development; 2) the effects of estrogen on neuronal morphology and on learning and memory; and, 3) the effects of aging on neuronal structure and function. We have focused our efforts on single neurons in the hippocampal formation, a region that is critical for certain forms of learning and memory in rodents and humans.\\nFrom the portal, you may click on a cell in your region of interest to see the complete database of cells from that region. You may also explore the Neuron Database:\\n* Comparative Electrotonic Analysis of Three Classes of Rat Hippocampal Neurons. (Raw data available)\\n* Quantitative, three-dimensional analysis of granule cell dendrites in the rat dentate gyrus.\\n* Dendritic Growth and Regression in Rat Dentate Granule Cells During Late Postnatal Development.(Raw data available)\\n* A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus.
2D mouse brain atlas of high quality coronal Nissl- and myelin-stained sections with labels, 3D images of hippocampal formation and limited other brain structures. The data for this digital atlas are based on the Atlas of the Mouse Brain and Spinal Cord, authored by Richard L. Sidman, Jay. B. Angevine and Elizabeth Taber Pierce, published as a hard cover book by Harvard University Press in 1971 and currently out of print. C57BL/6J strain adult specimens were used in creating the atlas.
Virtual database currently indexing multiple connectivity databases including:\\n* The Brain Architecture Management System (BAMS) - http://brancusi.usc.edu/bkms/\\n* Collations of Connectivity data on the Macaque brain (CoCoMac) - http://cocomac.org\\n* BrainMaps - http://brainmaps.org/\\n* Connectome Wiki - http://www.connectome.ch\\n* the Hippocampal-Parahippocampal table of Temporal-Lobe.com - http://www.temporal-lobe.com/\\n* Avian Brain Circuitry Database, http://www.behav.org/abcd/abcd.php\\nThese data come primarily from published work or expert opinion. It is likely that some differences in connectivity among brain regions may be due to differing opinion of brain region boundaries in addition to species differences.\\nAll data was fit from the source data to statements that have two connected regions, i.e., connection from and connection to with the region abbreviation first followed by the region full name. Thus, an afferent from hippocampus to cortex (in the source data) would be aligned to connection from cortex, connection to hippocampus. The connection strength was aligned from symbols and numbers into the following categories: heavy, moderate, weak, not detected, exists, and unknown. Publications are reported and links to PubMed have been added, where possible. All other information that was available and relevant from each source was concatenated into the notes column.\\nThe specifics of the alignment below:\\n* For CoCoMac the projection strength was translated as follows:\\n** when l2_nif_0000_00022_cocomac_connectivity.density = '0' then 'Not detected'\\n** when l2_nif_0000_00022_cocomac_connectivity.density = '1' then 'Weak'\\n** when l2_nif_0000_00022_cocomac_connectivity.density = '2' then 'Moderate'\\n** when l2_nif_0000_00022_cocomac_connectivity.density = '3' then 'Heavy'\\n** when l2_nif_0000_00022_cocomac_connectivity.density = 'X' then 'Exists'\\n* For BAMS database:\\n** lower (case when a.PROJECTION_STRENGTH like 'strong' then 'Heavy'\\n** when a.PROJECTION_STRENGTH like 'very strong' then 'Heavy'\\n** when a.PROJECTION_STRENGTH like 'light/moderate' then 'Moderate'\\n** when a.PROJECTION_STRENGTH like 'moderate' then 'Moderate'\\n** when a.PROJECTION_STRENGTH like 'light' then 'Weak'\\n** when a.PROJECTION_STRENGTH like 'very light' then 'Weak'\\n** when a.PROJECTION_STRENGTH like 'moderate/strong' then 'Heavy'\\n** when a.PROJECTION_STRENGTH like 'not present' then 'Not detected'\\n* For BrainMaps:\\n** when l2_nif_0000_00093_brainmaps_connectivity.strength like '++++' then 'Heavy'\\n** when l2_nif_0000_00093_brainmaps_connectivity.strength like '+++' then 'Moderate'\\n** else 'Unknown'
This database contains morphologies of hippocampal pyramidal cells and interneurons (in Neurolucida, NEURON, and pdf formats) as well as data recorded from those cells.\\nSponsors:This work was supported by grants from the NIH (T32-GM-08061 to T.J.M., F32-NS-10532 to N.L.G., and R01-NS35180 and R01-NS 46064 to N.S. and W.L.K.) and NSF (IGERT fellowship to Y.K.). NS46064 is part of the NSF/NIH Collaborative Research in Computational Neuroscience Program
A database of genes concerning adult neurogenesis mapped to cell types and processes that have been curated from the literature. In its present state, the database is restricted to neurogenesis in the hippocampus. Although the literature contains data from several species, for the sake of uniformity, all genes in the database are reported as the mouse homologue.\\nThe resource also contains a comprehensive survey of the literature to annotate the results of all published reports on gene function in adult hippocampal neurogenesis (257 manuscripts covering 228 genes) to the appropriate terms in our ontology\\nThe Mammalian Neurogenesis Gene Ontology was designed and curated by Gerd Kempermann and Rupert Overall\\nThe database was created by Maciej Paszkowski-Rogacz and Rupert Overall.\\nEach entry corresponds to a discrete effect of a gene as reported in a single study. Thus a study may report multiple effects for one gene, and several studies may report data for the same gene.
A 3D stereoscopic (anaglyph method) full brain functional connectivity atlas created using a parcellation atlas published by Craddock et al. (2012). Using 3D Slicer 3.6.3 and the two hundred Region of Interest (ROI) version of the Craddock atlas, 200 grayscale surface models were created using a z-stat threshold > 2.3, and each surface model was processed with a surface decimation algorithm, smoothed with the Taubin algorithm and without surface normals.\\nFor improved visualization of the functional connectivity networks and their relative anatomical position, the surface model of five subcortical anatomical structures (corpus callosum, bilateral caudate, pallidum, putamen, thalamus, amygdala and hippocampus) were included in SAIBN. These surfaces were created with 3D Slicer using the segmentation computed with Freesurfer v. 5.1.\\nThe viewer should use red-cyan glasses to see the 3D stereoscopic effect using 3D Slicer (version 3.6.3, http://www.slicer.org/pages/Special:SlicerDownloads).
Data set of virtually generated anatomically plausible neurons for several morphological classes, including cerebellar Purkinje cells, hippocampal pyramidal and granule cells, and spinal cord motoneurons.\\nTraced Neurons:\\n* Amaral Cell archive\\n* Neuron_Morpho reconstructions\\n* Mouse Alpha Motoneurons\\nGenerated Neurons:\\n* Motoneurons\\n* Purkinje Cells\\n* Hippocampal Pyramidal Cells\\nHippocampal Axonal Morphology\\nTwo major types of algorithms have been proposed for the generation and description of dendritic trees. Local algorithms rely entirely on a set of local rules correlating morphological parameters (such as branch diameter and length) to let each branch grow independent of the other dendrites in the tree and independent of its absolute position within the tree. In global algorithms, new dendritic branches are dealt from outside to competing groups of growing tips, also depending on their position in the tree (e.g. on their distance from the soma). They are developing two programs, L-Neuron and ArborVitae, which implement several global and local algorithms, to investigate systematically the potential of the computational neuroanatomy approach for neuroscience databases. \\nExperimental files of motoneuron morphology were provided by Dr. Burke's lab at the NIH. The relative data is described and published by Cullheim's et al., 1987 (PMID: 3819010)\\nExperimental files of Purkinje cell morphology were provided by Dr. Rapp at the Hebrew University. The relative data is described and published by Rapp et al., 1994 (PMID: 8014888).
NDRI is a Not-For-Profit (501c3) Corporation dedicated to providing the highest quality human biomaterials for research. NDRI makes it easy for researchers to get the human tissues and organs they need, prepared, preserved and shipped precisely according to their specific scientific protocols, as quickly as possible, and in the largest available quantities.\\nHuman cells, tissues, and organs are required to investigate how human disease progresses and to develop new drugs and therapies for treatments and cures. For over 25 years NDRI has served scientists with customized biomaterials for use in studies to understand human disease.\\nWe work everyday to help ensure that tissues and organs donated for medical research are shipped to the nation's top scientific laboratories for study. Tissues and organs donated for research should never be wasted.\\nNDRI provides researchers with protocol specific human neurological tissues such as: Brain Stem, Spinal Cord, Basal Ganglia, Cerebral Cortex, Hippocampus. In addition to control specimens, NDRI recovers tissues from donors with a variety of diseases including: Down's Syndrome, Parkinson's Disease, Alzheimer's Disease, Schizophrenia, Dementia. Through the NDRI 24/7 referral and procurement system, research consented biospecimens can be provided from low post mortem interval donors preserved at 4 degrees C, frozen or snap frozen, fixed, paraffin embedded or as unstained slides.
An autopsy-based, research-devoted brain bank, biobank and biospecimen bank that derives its human donors from the Arizona Study of Aging and Neurodegenerative Disease (AZSAND), a longitudinal clinicopathological study of the health and diseases of elderly volunteers living in Maricopa county and metropolitan Phoenix, Arizona. Their function is studied during life and their organs and tissue after death. To date, they have concentrated their studies on Alzheimer's disease, Parkinson's disease, heart disease and cancer. They share the banked tissue, biomaterials and biospecimens with qualified researchers worldwide. Registrants with suitable scientific credentials will be allowed access to a database of available tissue linked to relevant clinical information, and will allow tissue requests to be initiated.
A blog focusing on the function of adult neurogenesis in the dentate gyrus of the hippocampus, including discussion of scientific research papers, methods and protocols, and other trends or observations about the field.
A curated knowledge base of the circuitry of the hippocampus of normal adult, or adolescent, rodents at the mesoscopic level of neuronal types. Knowledge concerning dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex is distilled from published evidence and is continuously updated as new information becomes available. Each reported neuronal property is documented with a pointer to, and excerpt from, relevant published evidence, such as citation quotes or illustrations.\\nPlease note: This is an alpha-testing site. The content is still being vetted for accuracy and has not yet undergone peer-review. As such, it may contain inaccuracies and should not (yet) be trusted as a scholarly resource. The content does not yet appear uniformly across all combinations of browsers and screen resolutions.
Blog is first and foremost dedicated to circuitry, all the way from a small cluster of connections in a small brain area to wide-spread circuitry between several brain areas (local, regional and functional connectivity). My Philosophy (on neuroscience): I do not think that functions of the brain (and/or mind) can be localized to certain areas (modular zones). This is a distributed, interactive function in a neural network. Second, there is usually an underlying tone that relates to the hippocampus, and/or the post has a systems-level approach to it.\\nPostings will most likely be in a review-esque fashion. This is really meant to be an information resource. I hope to get more opinion pieces in there sometime. Posts are usually what I am currently researching, interested in, or what I have previously done research on at one time. I also want to build a community of professionals and others interested in neuroscience and/or psychology (philosophy of mind, too!). The blog, in general, helps everything (the information) stay fresh in my mind.