HomoloGene Tutorial

For up to date issues or problems with this database please see the wiki.
For more information, please visit HomoloGene.

HomoloGene is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.

To find data in this database, one should start with a search for any gene and in the case below we search for GRM1.

The results can be found in the Nervous System Level > Genes category.
This database view has been engineered to the following behavior: if someone searches for any term that is present in a particular cluster then the search will bring back all of the members of that cluster.  For example the mgl-2 for C. Elegans has no term that we searched for, but appears in this cluster so it will be retrieved.

Clicking on the cluster number takes the user to the HomoloGene resource at NCBI.  The landing page is always the ‘cluster landing page’ where all of the members of a cluster can be compared.  From here clicking on any gene will bring the user to entrez gene database and clicking on the protein links will bring users to the corresponding NCBI protein page.

For more information, please visit HomoloGene.